Tanguy Ndombele, Ryan Sessegnon, Kyle Walker-Peters and Eric Dier have all returned to training and are being assessed for selection against Crystal Palace this weekend.
Central midfielder Tanguy missed our last two games before the international break over a thigh problem while fellow new signing Ryan has been sidelined since his arrival from Fulham with a hamstring injury.
Right-back Kyle and versatile defender Eric missed the trip to Arsenal last time out with respective hamstring and hip issues.
As reported earlier this week, attacking midfielder Giovani Lo Celso is undergoing rehabilitation for a hip injury sustained on international duty with Argentina and is unavailable for selection.
Central defender Davinson Sanchez, meanwhile, is being assessed after complaining of irritation in his ankle following his involvement for Colombia this week.
Fellow defender Juan Foyth is concluding the late stages of conditioning following his own ankle injury before returning to training with the squad. He remains unavailable to face Palace.
Kick-off at the new stadium on Saturday is at 3pm.