Jose Mourinho will be without the services of Erik Lamela, Hugo Lloris and Michel Vorm for his first match in charge away to West Ham United on Saturday.
Attacking midfielder Erik and goalkeeper Hugo are continuing rehabilitation from respective hamstring and elbow injuries and are unavailable this weekend.
Fellow stopper Michel sustained a calf strain in training on Monday and is expected to return to training next month.
Meanwhile, midfielder Tanguy Ndombele (groin) and Jan Vertonghen (hamstring) are beginning reintegration into training and will be assessed ahead of Saturday’s match.
Kick-off at the London Stadium is at 12.30pm.