Ben Davies has been ruled out of Tuesday night’s clash with Olympiacos.
The Welsh international left-back sustained an ankle injury in Saturday’s Premier League win over West Ham and is currently undergoing assessment.
However, there is good news on defender Jan Vertonghen and midfielder Tanguy Ndombele.
Jan has had a hamstring injury and Tanguy a groin problem, but both have now returned to training with the squad.
Erik Lamela (hamstring), Hugo Lloris (elbow) and Michel Vorm (calf) are continuing rehabilitation and remain out.
Kick-off at Tottenham Hotspur Stadium is at 8pm.