Hugo Lloris has returned to training and is available for selection ahead of Wednesday night's mouth-watering Champions League clash with Barcelona.
The goalkeeper has been sidelined with a thigh problem in recent weeks and last appeared for the team in the 3-0 win at Manchester United at the end of August.
Fellow goalkeeper Michel Vorm (knee) is expected to return to training later this week.
Ruled out are Dele Alli (hamstring), Serge Aurier (thigh), Mousa Dembele (thigh), Christian Eriksen (abdomen) and Jan Vertonghen (hamstring).
The quintet will not be available before the international break.
Mauricio Pochettino added: "It’s a good opportunity for many players, they will have the possibility to play. It will be an exciting game, an important game for us after the defeat against Inter and in front of us, one of the best teams in Europe."